The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?

@article{Nieoullon2006TheNE,
  title={The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?},
  author={Andr{\'e} L Nieoullon and Benoit Canolle and Fr{\'e}d{\'e}rique M Masmejean and Benjamin Guillet and Pascale Pisano and Sylviane Lortet},
  journal={Journal of Neurochemistry},
  year={2006},
  volume={98}
}
EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post‐synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Although, in the adult, EAAC1/EAAT3 exhibits a rather low expression level and is considered to make a minor contribution to Glu removal from the synapse, its early expression during brain development, before the astrocytes are functional… 
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Regulation of Glutamate Transporter Expression in Glial Cells.
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The identification of these mechanisms has allowed to understand the role of Glu transporters during pathology and will aid in the development of therapeutic strategies for treating or preventing pathologies associated with excitotoxicity.
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