The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?

  title={The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?},
  author={Andr{\'e} L. Nieoullon and Benoit Canolle and Fr{\'e}d{\'e}rique M. Masmejean and Benjamin Guillet and Pascale Pisano and Sylviane Lortet},
  journal={Journal of Neurochemistry},
EAAC1/EAAT3 is a transporter of glutamate (Glu) present at the post‐synaptic neuronal element, in opposition to the two other main transporters, GLAST/EAAT1 and GLT1/EAAT2, expressed at the excitatory amino acid (EAA) synapse by surrounding astrocytes. Although, in the adult, EAAC1/EAAT3 exhibits a rather low expression level and is considered to make a minor contribution to Glu removal from the synapse, its early expression during brain development, before the astrocytes are functional… 

Modulation of EAAC1-Mediated Glutamate Uptake by Addicsin

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These data rule against a possible role for EAAC1 in the clearance of glutamate from within the cleft and in the regulation of its time in the synapse, and suggest an unconventional non‐synaptic function of this high‐affinity glutamate carrier, not restricted to glutamatergic fibres.

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Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse

It is suggested that genetically EAAC1-null (Slc1a1−/−) mice have reduced neuronal glutathione levels and, with aging, develop brain atrophy and behavioral changes, and thatEAAC1 deficiency thereby leads to impaired neuronal glutATHione metabolism, oxidative stress and age-dependent neurodegeneration.

The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures

The findings suggest that neuronal EAAT activity can be a rate‐limiting step for neuronal glutathione synthesis and that the primary function of EAATs expressed by neurons in vivo may be to transport cysteine.

Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.

Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit gluR2 in the rat hippocampus

EAAC1, a neuron‐specific glutamate transporter, is likely to play an important role in the regulation of glutamate levels in the synaptic cleft. Ultrastructural studies have demonstrated that the

Excitatory amino acid transporters: a family in flux.

This review summarizes current knowledge of the structural and functional diversity of excitatory amino acid transporters and explores how they might serve as targets for drug design.