The neuron-glia signal beta-neuregulin promotes Schwann cell motility via the MAPK pathway.

@article{Meintanis2001TheNS,
  title={The neuron-glia signal beta-neuregulin promotes Schwann cell motility via the MAPK pathway.},
  author={Stathis Meintanis and Dimitra Thomaidou and Kristj{\'a}n R. Jessen and Rhona Mirsky and Rebecca Matsas},
  journal={Glia},
  year={2001},
  volume={34 1},
  pages={39-51}
}
Neuregulins constitute a family of related growth factors that play important roles in Schwann cell development and maturation. We investigated the involvement of beta-neuregulin in Schwann cell migration, using a simple in vitro bioassay. Pure Schwann cells were prepared from the sciatic nerves of 5-day-old rats and were grown in defined medium, with or without serum, until a monolayer of confluent cells was formed. A cell-free area was then generated by inflicting a scratch resulting in a 1… CONTINUE READING

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