The neuromuscular activity of Micrurus pyrrhocryptus venom and its neutralization by commercial and specific coral snake antivenoms

@inproceedings{Camargo2011TheNA,
  title={The neuromuscular activity of Micrurus pyrrhocryptus venom and its neutralization by commercial and specific coral snake antivenoms},
  author={Thiago Magalh{\~a}es Camargo and Adolfo Rafael de Roodt and Maria Alice da Cruz-H{\"o}fling and L{\'e}a Rodrigues-Simioni},
  booktitle={Journal of venom research},
  year={2011}
}
The neuromuscular activity ofMicrurus pyrrochryptus venom was studied in chick biventer cervicis (BC) and mouse phrenic nerve-diaphragm (PND) preparations. The venom (0.5-50μg/ml) caused irreversible, time- and concentration-dependent blockade, with BC being more sensitive than PND (50% blockade with 10μg/ml in 22±;3min and 62±4min, respectively; mean±SEM, n=6; p<0.05). In BC preparations, venom (0.5μg/ml) progressively abolished ACh-induced contractures, whereas contractures to exogenous KCl… CONTINUE READING

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