The neurokinin-1 receptor in addictive processes.

@article{Schank2014TheNR,
  title={The neurokinin-1 receptor in addictive processes.},
  author={Jesse R Schank},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2014},
  volume={351 1},
  pages={
          2-8
        }
}
Stress can trigger drug-seeking behavior, increase self-administration rates, and enhance drug reward. A number of stress-related neuropeptides have been shown to mediate these behavioral processes. The most studied peptide in this category is corticotropin-releasing hormone (CRH), which has been shown to mediate stress-induced reinstatement of drug seeking, escalated self-administration, and drug withdrawal, but it does not seem to be involved in baseline drug self-administration or cue… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

Substance P and the Neurokinin-1 Receptor: The New CRF.

VIEW 1 EXCERPT
CITES BACKGROUND

The Role of NFkB in Drug Addiction: Beyond Inflammation

VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 87 REFERENCES

Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Neurokinin-1 receptorexpressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse

  • CA Gadd, P Murtra, C De Felipe, SP Hunt
  • J Neurosci
  • 2003
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function.

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL