The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [<ce:sup loc=pre>11</ce:sup>C]PBR28 PET study

@article{Hannestad2013TheNM,
  title={The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: A [<ce:sup loc=pre>11</ce:sup>C]PBR28 PET study},
  author={Jonas O Hannestad and Nicole Dellagioia and Jean-Dominique Gallezot and Keunpoong Lim and Richard E. Carson},
  journal={Brain, Behavior, and Immunity},
  year={2013},
  volume={33},
  pages={131-138}
}
Depression is associated with systemic inflammation. In animals, systemic inflammation can induce neuroinflammation and activation of microglia; however, postmortem studies have not convincingly shown that there is neuroinflammation in depression. The purpose of this study was to use positron emission tomography (PET) with [¹¹C]PBR28, which binds to the neuroinflammation marker translocator protein 18 kDa (TSPO), to compare the level of TSPO between individuals with depression and control… CONTINUE READING
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