The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritis.

@article{Catalano2010TheNS,
  title={The neuroimmune semaphorin-3A reduces inflammation and progression of experimental autoimmune arthritis.},
  author={Alfonso Catalano},
  journal={Journal of immunology},
  year={2010},
  volume={185 10},
  pages={6373-83}
}
Semaphorin-3A (Sema3A), a member of a large family of conserved proteins originally implicated in axon guidance, is expressed by activated T cells and downmodulates T cell activation in vitro. This study examined the effect and mechanism of action of Sema3A overexpression in a mouse model of collagen-induced arthritis. Prophylactic i.p. administration of plasmid DNA encoding Sema3A markedly reduced the incidence, disease severity, and articular inflammation compared with control plasmid without… CONTINUE READING