The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting macrophage emigration from plaques

@inproceedings{Gils2012TheNG,
  title={The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting macrophage emigration from plaques},
  author={Janine M. van Gils and Merran C Derby and Luciana Rodrigues Fernandes and Bhama Ramkhelawon and Tathagat Dutta Ray and Katey J. Rayner and Sajesh Parathath and Emilie Distel and J L Feig and Jacqueline Isaura Alvarez-Leite and Alistair J Rayner and Thomas O. McDonald and Kevin D. O’Brien and Lynda M Stuart and Edward A Fisher and Adam Lacy-Hulbert and Kathryn J. Moore},
  booktitle={Nature Immunology},
  year={2012}
}
Atherosclerotic plaque formation is fueled by the persistence of lipid-laden macrophages in the artery wall. The mechanisms by which these cells become trapped, thereby establishing chronic inflammation, remain unknown. Here we found that netrin-1, a neuroimmune guidance cue, was secreted by macrophages in human and mouse atheroma, where it inactivated the migration of macrophages toward chemokines linked to their egress from plaques. Acting via its receptor, UNC5b, netrin-1 inhibited the… CONTINUE READING
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Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia

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