The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure.

@article{Packer1992TheNH,
  title={The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure.},
  author={Milton Packer},
  journal={Journal of the American College of Cardiology},
  year={1992},
  volume={20 1},
  pages={
          248-54
        }
}
Because physicians have traditionally considered heart failure to be a hemodynamic disorder, they have described the syndrome of heart failure using hemodynamic concepts and have designed treatment strategies to correct the hemodynamic derangements of the disease. However, although hemodynamic abnormalities may explain the symptoms of heart failure, they are not sufficient to explain the progression of heart failure and, ultimately, the death of the patient. Therapeutic interventions may… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 344 CITATIONS

Increased thirst and vasopressin secretion after myocardial infarction in rats.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2003
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Higher expectations for management of heart failure: current recommendations.

  • The Journal of the American Board of Family Practice
  • 2002
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

EFFECTS OF DIGOXIN AND IBOPAMINE IN HEART FAILURE

  • 2004
VIEW 5 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

Beta Blockers in Heart Failure: Issues in Management of Individual Patients

  • Heart Failure Reviews
  • 1999
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Brain "ouabain" and angiotensin II contribute to cardiac dysfunction after myocardial infarction.

  • The American journal of physiology
  • 1999
VIEW 4 EXCERPTS
CITES RESULTS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1993
2019

CITATION STATISTICS

  • 10 Highly Influenced Citations

  • Averaged 12 Citations per year over the last 3 years

Similar Papers

Loading similar papers…