The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate

Abstract

The phosphorylated carboxyl-terminal "tail" domains of the neurofilament (NF) subunits, NF heavy (NF-H) and NF medium (NF-M) subunits, have been proposed to regulate axon radial growth, neurofilament spacing, and neurofilament transport rate, but direct in vivo evidence is lacking. Because deletion of the tail domain of NF-H did not alter these axonal… (More)

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Cite this paper

@article{Rao2003TheNM, title={The neurofilament middle molecular mass subunit carboxyl-terminal tail domains is essential for the radial growth and cytoskeletal architecture of axons but not for regulating neurofilament transport rate}, author={Mala Rao and Jabbar Campbell and Aidong Yuan and Asok Kumar and Takahiro Gotow and Yasuo Uchiyama and Ralph A. Nixon}, journal={The Journal of Cell Biology}, year={2003}, volume={163}, pages={1021 - 1031} }