The neurocircuitry of obsessive–compulsive disorder and disgust

  title={The neurocircuitry of obsessive–compulsive disorder and disgust},
  author={David S. Husted and Nathan Andrew Shapira and Wayne K. Goodman},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},

Disgust in Anxiety and Obsessive-Compulsive Disorders: Recent Findings and Future Directions

Recent evidence implicating disgust in anxiety and OCD is examined, highlighting recent measurement and methodological improvements and an increased focus on disgust-related mechanisms that contribute to psychopathology, such as disgust-based learning and emotion regulation.

Neuroimaging of psychotherapy for obsessive–compulsive disorder: A systematic review

Looking beyond fear: the extinction of other emotions implicated in anxiety disorders.

Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder

Given the putative mechanistic overlap between OCD and the broader OC-spectrum of disorders, unraveling the synaptic basis of OCD has potential to translate into more effective treatments for an array of poorly understood human disorders.

A Psycho-Behavioral Perspective on Modelling Obsessive-Compulsive Disorder (OCD) in Animals: The Role of Context.

The psychobehavioral aspects of OCD that are of importance on how the above ideas can be articulated are reviewed, and novel behavioral constructs for future investigations that may contribute to the face, predictive and construct validity of OCD animal models are identified.

Disgust Recognition in Obsessive-Compulsive Disorder: Diagnostic Comparisons and Posttreatment Effects

Support is provided for the presence of disgust recognition impairment in OCD, and preliminary evidence that disgust recognition impairments may improve with treatment is provided.

Neural Circuitry in Obsessive Compulsive Disorder: an fMRI Study of the Effect of IV Citalopram

The effects observed after the IV citalopram infusion are similar to modulations observed after prolonged oral pharmacotherapy trials, illustrating the benefits of IV SRIs.



The psychobiology of obsessive-compulsive disorder: How important is the role of disgust?

Findings on disgust and its mediating CSTC circuits may generate useful hypotheses for OCD research, as psychobiologic models of panic disorder and posttraumatic stress disorder have been strengthened by the inclusion of preclinical work on amygdala-mediated fear conditioning.

The cognitive-affective neuroscience of obsessive-compulsive disorder

There is substantial evidence that obsessive-compulsive disorder (OCD) is mediated by specific cortico-striatalthalamic-cortical circuits and this model is becoming integrated with a range of data including brain imaging, genetic, immunologic, and neurochemical findings.

Disgust implicated in obsessive–compulsive disorder

Impaired recognition of disgust is consistent with the neurology of OCD and with the idea that abnormal experience of disgust may be involved in the genesis of obsessions and compulsions.

Hemodynamic responses to fear and disgust-inducing pictures: an fMRI study.

  • R. StarkA. Schienle D. Vaitl
  • Psychology, Biology
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2003