The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y

@article{Kask2002TheNA,
  title={The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y},
  author={Ants Kask and Jaanus Harro and Stephan von H{\"o}rsten and John Paul Redrobe and Yvan Dumont and Rémi Quirion},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2002},
  volume={26},
  pages={259-283}
}
This review aims to give a brief overview of NPY receptor distribution and physiology in the brain and summarizes series of studies, test by test and region by region, aimed at identification receptor subtypes and neuronal circuitry mediating anxiolytic-like effects of NPY. We conclude that from four known NPY receptor subtypes in the rat (Y(1), Y(2), Y(4), Y(5)), only the NPY Y(1) receptor can be linked to anxiety-regulation with certainty in the forebrain, and that NPY Y(2) receptor may have… Expand
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Testing the effects of intracerebroventricular injection of NPY as well as specific receptor agonists for the Y1 receptor, Y2 receptor, and Y5 receptor in the elevated plus maze and open field tests indicates that anxiolytic‐like effects of i.c.v.‐administered NPY in rats are mediated via both Y1 andY5 receptors, whereas sedation is mediated via Y5 receptors. Expand
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Infusions of neuropeptide Y into the lateral septum reduce anxiety-related behaviors in the rat
TLDR
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  • Neuropeptides
  • 2004
TLDR
Information is provided on several brain structures involved in mediating anti-stress actions of NPY, with the most extensive evidence available for amygdala and hippocampus, and some evidence for regions within the septum, and locus coeruleus. Expand
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TLDR
It has been demonstrated that NPY produces not only an anxiolytic effect through Y1-type receptors, but also an anxiogenic effect via Y2- type receptors. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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