The neurobiology of pain perception in normal and persistent pain.

  title={The neurobiology of pain perception in normal and persistent pain.},
  author={Bradford W. Fenton and Elim Shih and Jessica R. Zolton},
  journal={Pain management},
  volume={5 4},
Pain is a significant national burden in terms of patient suffering, expenditure and lost productivity. Understanding pain is fundamental to improving evaluation, treatment and innovation in the management of acute and persistent pain syndromes. Pain perception begins in the periphery, and then ascends in several tracts, relaying at different levels. Pain signals arrive in the thalamus and midbrain structures which form the pain neuromatrix, a constantly shifting set of networks and connections… 

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