The neurobiology of itch

  title={The neurobiology of itch},
  author={A. Ikoma and M. Steinhoff and S. St{\"a}nder and G. Yosipovitch and M. Schmelz},
  journal={Nature Reviews Neuroscience},
  • A. Ikoma, M. Steinhoff, +2 authors M. Schmelz
  • Published 2006
  • Medicine
  • Nature Reviews Neuroscience
  • The neurobiology of itch, which is formally known as pruritus, and its interaction with pain have been illustrated by the complexity of specific mediators, itch-related neuronal pathways and the central processing of itch. Scratch-induced pain can abolish itch, and analgesic opioids can generate itch, which indicates an antagonistic interaction. However, recent data suggest that there is a broad overlap between pain- and itch-related peripheral mediators and/or receptors, and there are… CONTINUE READING
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