The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback.

@article{Nicholson2017TheNO,
  title={The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback.},
  author={Andrew A Nicholson and Daniela Rabellino and Maria Densmore and Paul A. Frewen and Christian Paret and Rosemarie Kluetsch and Christian Schmahl and Jean Th{\'e}berge and Richard W. J. Neufeld and Margaret C. McKinnon and Jim Reiss and Rakesh Jetly and Ruth A. Lanius},
  journal={Human brain mapping},
  year={2017},
  volume={38 1},
  pages={541-560}
}
Amygdala dysregulation has been shown to be central to the pathophysiology of posttraumatic stress disorder (PTSD) representing a critical treatment target. Here, amygdala downregulation was targeted using real-time fMRI neurofeedback (rt-fMRI-nf) in patients with PTSD, allowing us to examine further the regulation of emotional states during symptom provocation. Patients (n = 10) completed three sessions of rt-fMRI-nf with the instruction to downregulate activation in the amygdala, while… CONTINUE READING
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