The neurobiology of addiction.

@article{Maldonado2003TheNO,
  title={The neurobiology of addiction.},
  author={Rafael Maldonado},
  journal={Journal of neural transmission. Supplementum},
  year={2003},
  volume={66},
  pages={1-14}
}
Drug addiction includes complex neurobiological and behavioural processes. Acute reinforcing effects of drugs of abuse are responsible for the initiation of drug addiction, whereas the negative consequences of drug abstinence have a crucial motivational significance for relapse and maintenance of the addictive process. The mesocorticolimbic system represents a common neuronal substrate for the reinforcing properties of drugs of abuse. Both dopamine and opioid transmission play a crucial role in… CONTINUE READING

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