The neurobiology of acetyl-L-carnitine.

@article{Traina2016TheNO,
  title={The neurobiology of acetyl-L-carnitine.},
  author={Giovanna Traina},
  journal={Frontiers in bioscience},
  year={2016},
  volume={21},
  pages={
          1314-29
        }
}
  • G. Traina
  • Published 1 June 2016
  • Biology
  • Frontiers in bioscience
A large body of evidence points to the positive effects of dietary supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in neuroinflammation, which is a common denominator in a host of neurodegenerative diseases. ALC is the principal acetyl ester of L-Carnitine (LC), and it plays an essential role in intermediary metabolism, acting as a donor of acetyl groups and facilitating the transfer of fatty acids from cytosol to mitochondria during beta-oxidation. Dietary… 

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Evidence that carnitine analogs play many roles in serious diseases and treatments is summarized, suggesting that ALC can affect several targets in the central nervous system.

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Evidence that ALC controls genes involved in these serious neurological pathologies is provided and insights into the ways in which ALC might exert its therapeutic benefits are provided.
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