The neurobiology of MMN and implications for schizophrenia

@article{Michie2016TheNO,
  title={The neurobiology of MMN and implications for schizophrenia},
  author={Patricia T. Michie and Manuel S. Malmierca and Lauren R. Harms and Juanita Todd},
  journal={Biological Psychology},
  year={2016},
  volume={116},
  pages={90-97}
}
Although the scientific community appears to know a lot about MMN, about its neural generators and the computational processes that underlie its generation, do we have sufficient knowledge to understand what causes the reduction of MMN amplitude in schizophrenia? Here we attempt to integrate the evidence presented in this series of papers for the special issue on MMN in schizophrenia together with evidence from other new relevant research and ask--what have we learnt? While MMN research was the… Expand
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36 Citations
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36 Citations

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Understanding the neurobiology of MMN and its reduction in schizophrenia
TLDR
This Special Issue on MMN and Schizophrenia arose out of a orkshop, held in Newcastle, Australia prior to the 12th International Conference on Cognitive Neuoscience (ICON2014) in Brisbane, in July, 2014, to arrive at a better understanding of why MMN is educed in schizophrenia. Expand
Event Related Potential Studies and Findings: Schizophrenia as a Disorder of Cognition
Schizophrenia is a serious mental illness that is characterized by a wide range of cognitive impairments and a constellation of symptoms. With the advent of event related potential (ERP) methodology,… Expand
Reduced Auditory Mismatch Negativity Reflects Impaired Deviance Detection in Schizophrenia
TLDR
The use of the many-standards paradigm for deconstructing the constituent processes underlying the MMN is supported, with implications for the use of these translational measures to accelerate the development of new treatments that target perceptual and cognitive impairments in schizophrenia and related disorders. Expand
Language Dysfunction in Schizophrenia: Assessing Neural Tracking to Characterize the Underlying Disorder(s)?
TLDR
It is proposed to combine naturalistic stimulation, measures of speech–brain synchronization, and computational modeling of abstract linguistic knowledge and predictions to lead to a mechanistic understanding of the deficits underlying language related disorder(s) in schizophrenia. Expand
Event-Related Potentials in the Clinical High-Risk (CHR) State for Psychosis: A Systematic Review
TLDR
Across studies, amplitudes of the auditory P300 and duration mismatch negativity (MMN) ERPs appear reliably reduced in CHR individuals, suggesting that underlying impairments in detecting changes in auditory stimuli are a sensitive early marker of the psychotic disease process. Expand
Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences
TLDR
While the results suggest continuity in backward connectivity alterations with psychotic-like experiences regardless of diagnosis, they also point to specificity for the schizophrenia spectrum disorder group in interhemispheric connectivity alterations. Expand
Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences
TLDR
While the results suggest continuity in backward connectivity alterations with psychotic-like experiences regardless of diagnosis, they also point to specificity for the schizophrenia spectrum disorder group in interhemispheric connectivity alterations. Expand
Schizotypy and auditory mismatch negativity in a non-clinical sample of young adults
TLDR
The trend-level association between MMN and Suspiciousness is in contrast to the robustly attenuated MMN amplitude observed in schizophrenia, which may reflect a schizophrenia-disease state, whereas non-clinical schizotypy may not be subserved by similar neuropathology. Expand
Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents
TLDR
It is hypothesized that SSA reflects adaptations occurring at synapses along the sensory-thalamocortical pathways, while DD depends on both SSA inherited from afferent inputs and resulting disinhibition of non-adapted neurons arising from the distinct physiology and wiring properties of local interneuronal subpopulations and NMDA-receptor function. Expand
Cognitive neurophysiology: Event-related potentials.
TLDR
It is argued that analyses of time-locked responses are beneficial to assess nonlinear and nonsinusoidal neuronal activity on a fine-grained temporal scale, since analyses in the time domain are less susceptible to artifacts than spectral decomposition techniques. Expand
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