The neurobiology of MMN and implications for schizophrenia

  title={The neurobiology of MMN and implications for schizophrenia},
  author={Patricia T. Michie and Manuel S. Malmierca and Lauren Harms and Juanita Todd},
  journal={Biological Psychology},
Event Related Potential Studies and Findings: Schizophrenia as a Disorder of Cognition
The aim is to present the current state of research on neurophysiological underpinnings of schizophrenia that uses ERPs as a research tool and to point to major present and future trends within this field.
Reduced Auditory Mismatch Negativity Reflects Impaired Deviance Detection in Schizophrenia
The use of the many-standards paradigm for deconstructing the constituent processes underlying the MMN is supported, with implications for the use of these translational measures to accelerate the development of new treatments that target perceptual and cognitive impairments in schizophrenia and related disorders.
Language Dysfunction in Schizophrenia: Assessing Neural Tracking to Characterize the Underlying Disorder(s)?
It is proposed to combine naturalistic stimulation, measures of speech–brain synchronization, and computational modeling of abstract linguistic knowledge and predictions to lead to a mechanistic understanding of the deficits underlying language related disorder(s) in schizophrenia.
Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences
While the results suggest continuity in backward connectivity alterations with psychotic-like experiences regardless of diagnosis, they also point to specificity for the schizophrenia spectrum disorder group in interhemispheric connectivity alterations.
Schizotypy and auditory mismatch negativity in a non-clinical sample of young adults
Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents
It is hypothesized that SSA reflects adaptations occurring at synapses along the sensory-thalamocortical pathways, while DD depends on both SSA inherited from afferent inputs and resulting disinhibition of non-adapted neurons arising from the distinct physiology and wiring properties of local interneuronal subpopulations and NMDA-receptor function.
Cognitive neurophysiology: Event-related potentials.
Cortical excitation-inhibition ratio mediates the effect of pre-attentive auditory processing deficits on interpersonal difficulties
The findings support the growing body of literature pointing toward an excitation-inhibition imbalance that is central to psychosocial functioning across multi-dimensional spectrum disorders, such as autism and schizophrenia, and provides neurochemical indicators of the processes that underlie psychossocial dysfunction.


Mismatch Negativity: Translating the Potential
The utility of this tool in revealing the nature and time course of problems in perceptual inference in schizophrenia together with its potential for use in translational research testing animal models of schizophrenia-related phenotypes is addressed.
Criteria for determining whether mismatch responses exist in animal models: Focus on rodents
Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders
It is proposed that mismatch negativity (MMN)—a neurophysiological measure of central auditory system functioning—may be informative in developing the next generation of neuroscience-guided cognitive-enhancing treatments.
Future clinical uses of neurophysiological biomarkers to predict and monitor treatment response for schizophrenia
MMN is sensitive to and/or predicts response to some pharmacologic and nonpharmacologic interventions and accounts for substantial portions of variance in clinical, cognitive, and psychosocial functioning in schizophrenia (SZ), and this measure has recently been validated for use in large‐scale multisite clinical studies of SZ.
Neural Synchrony in Cortical Networks: History, Concept and Current Status
Evidence is presented that indicates that in addition to supporting conscious cognition, neural synchrony is abnormal in major brain disorders, such as schizophrenia and autism spectrum disorders.
What are the functional consequences of neurocognitive deficits in schizophrenia?
  • M. Green
  • Psychology, Medicine
    The American journal of psychiatry
  • 1996
OBJECTIVE It has been well established that schizophrenic patients have neurocognitive deficits, but it is not known how these deficits influence the daily lives of patients. The goal of this review
Mismatch negativity in schizophrenia: a meta-analysis
Neurophysiological models for new treatment development in schizophrenia: early sensory approaches
  • D. Javitt
  • Psychology, Biology
    Annals of the New York Academy of Sciences
  • 2015
Electroencephalography‐based neurophysiological measures, such as event‐related potentials (ERPs) or event-related spectral perturbations (ERSPs), are reviewed as novel translational biomarkers for both etiological and treatment development research in neuropsychiatry.