The neurobiology of MMN and implications for schizophrenia

@article{Michie2016TheNO,
  title={The neurobiology of MMN and implications for schizophrenia},
  author={Patricia T. Michie and Manuel S. Malmierca and Lauren Harms and Juanita Todd},
  journal={Biological Psychology},
  year={2016},
  volume={116},
  pages={90-97}
}
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doi.org
41 Citations
Background Citations
12
Methods Citations
2

41 Citations

Semantic priming and neurobiology in schizophrenia: A theoretical review
Event Related Potential Studies and Findings: Schizophrenia as a Disorder of Cognition
TLDR
The aim is to present the current state of research on neurophysiological underpinnings of schizophrenia that uses ERPs as a research tool and to point to major present and future trends within this field.
Reduced Auditory Mismatch Negativity Reflects Impaired Deviance Detection in Schizophrenia
TLDR
The use of the many-standards paradigm for deconstructing the constituent processes underlying the MMN is supported, with implications for the use of these translational measures to accelerate the development of new treatments that target perceptual and cognitive impairments in schizophrenia and related disorders.
Language Dysfunction in Schizophrenia: Assessing Neural Tracking to Characterize the Underlying Disorder(s)?
TLDR
It is proposed to combine naturalistic stimulation, measures of speech–brain synchronization, and computational modeling of abstract linguistic knowledge and predictions to lead to a mechanistic understanding of the deficits underlying language related disorder(s) in schizophrenia.
Aberrant connectivity in auditory precision encoding in schizophrenia spectrum disorder and across the continuum of psychotic-like experiences
TLDR
While the results suggest continuity in backward connectivity alterations with psychotic-like experiences regardless of diagnosis, they also point to specificity for the schizophrenia spectrum disorder group in interhemispheric connectivity alterations.
Schizotypy and auditory mismatch negativity in a non-clinical sample of young adults
Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents
TLDR
It is hypothesized that SSA reflects adaptations occurring at synapses along the sensory-thalamocortical pathways, while DD depends on both SSA inherited from afferent inputs and resulting disinhibition of non-adapted neurons arising from the distinct physiology and wiring properties of local interneuronal subpopulations and NMDA-receptor function.
Cognitive neurophysiology: Event-related potentials.
Cortical excitation-inhibition ratio mediates the effect of pre-attentive auditory processing deficits on interpersonal difficulties
TLDR
The findings support the growing body of literature pointing toward an excitation-inhibition imbalance that is central to psychosocial functioning across multi-dimensional spectrum disorders, such as autism and schizophrenia, and provides neurochemical indicators of the processes that underlie psychossocial dysfunction.
Decreased mismatch negativity and elevated frontal-lateral connectivity in first-episode psychosis.
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References

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TLDR
The utility of this tool in revealing the nature and time course of problems in perceptual inference in schizophrenia together with its potential for use in translational research testing animal models of schizophrenia-related phenotypes is addressed.
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Mismatch negativity is a breakthrough biomarker for understanding and treating psychotic disorders
TLDR
It is proposed that mismatch negativity (MMN)—a neurophysiological measure of central auditory system functioning—may be informative in developing the next generation of neuroscience-guided cognitive-enhancing treatments.
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