The neurobiology and pharmacotherapy of Alzheimer's disease.

  title={The neurobiology and pharmacotherapy of Alzheimer's disease.},
  author={O Felician and T A Sandson},
  journal={The Journal of neuropsychiatry and clinical neurosciences},
  volume={11 1},
Alzheimer's disease (AD), the most common cause of dementia, has become a major public health concern as our population ages. In recent years, AD has attracted the attention of a wide range of biological disciplines, and substantial progress has been made in understanding the mechanisms of neurodegeneration in AD. Four different genes have now been associated with AD and are providing insights into the pathogenesis of the disease. The roles of beta-amyloid, tau, hormonal changes, inflammation… CONTINUE READING