923 Citations
Serotonin and the neurobiology of anxious states
- Psychology, BiologyHandbook of Behavioral Neuroscience
- 2020
The Role of the Amygdala in Anxiety Disorders
- Psychology
- 2012
Anxiety is a term often used to encompass feelings of apprehension, dread, unease or similarly unpleasant emotions. Trait anxiety defines the affect of an organism over time and across situations,…
The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders.
- Psychology, BiologyCentral nervous system agents in medicinal chemistry
- 2010
The reviewed results suggest that chronic, but not acute, administration of antidepressants suppress panic attacks by increasing the release of 5-HT and enhancing the responsivity of post-synaptic 5- HT1A and5-HT2A receptors in the DPAG.
New perspectives in glutamate and anxiety
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 2012
Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray.
- Biology, PsychologyCellular and molecular neurobiology
- 2022
Evidence is document evidence suggesting that the PAG-evoked behavioral responses of anxiety, panic, fear, analgesia, and aggression are influenced by the activation of 5-HT1A and 5- HT2A/C receptors and their participation in the treatment of various mental disorders.
Serotonin in anxiety and panic: Contributions of the elevated T-maze
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
- 2014
Mesolimbic dopaminergic pathways in fear conditioning
- Psychology, BiologyProgress in Neurobiology
- 2004
Interactions between NPY and CRF in the amygdala to regulate emotionality
- Biology, PsychologyNeuropeptides
- 2004
Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders.
- Psychology, BiologyHandbook of experimental pharmacology
- 2005
This chapter discusses studies showing that CRH and the urocortins influence several aspects of serotoninergic neurotransmission, including the firing rate of 5-HT neurones and the release and synthesis of this monoamine, and reviews data showing that long-term alterations in the CRH system lead to aberrant functioning of serotonin allergic neurotransmission under basal and/or stressful conditions.
References
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- Biology, PsychologyTrends in Neurosciences
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Role of 5-HT in stress, anxiety, and depression
- Biology, PsychologyPharmacology Biochemistry and Behavior
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Corticosteroids in relation to fear, anxiety and psychopathology
- Psychology, BiologyNeuroscience & Biobehavioral Reviews
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The Vogel conflict test: procedural aspects, γ-aminobutyric acid, glutamate and monoamines
- Biology, Psychology
- 2003
The relevance of neuronal substrates of defense in the midbrain tectum to anxiety and stress: empirical and conceptual considerations.
- Biology, PsychologyEuropean journal of pharmacology
- 2003
Role of the amygdala and periaqueductal gray in anxiety and panic
- Biology, PsychologyBehavioural Brain Research
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Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
- PsychologyMolecular Psychiatry
- 2002
The mediators and circuitries of the stress system are reviewed to lay the groundwork for placing in context physiologic and structural alterations in depression that may occur as part of stress system dysfunction.
INDUCTION OF CORTICOTROPIN-RELEASING HORMONE GENE EXPRESSION BY GLUCOCORTICOIDS: IMPLICATION FOR UNDERSTANDING THE STATES OF FEAR AND ANXIETY AND ALLOSTATIC LOAD
- Biology, PsychologyPsychoneuroendocrinology
- 1998
Modulatory effects of norepinephrine, acting on alpha1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress
- Biology, PsychologyNeuropharmacology
- 2002
Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
- Psychology, BiologyProceedings of the National Academy of Sciences of the United States of America
- 2002
Findings point to a role for vasopressin in the modulation of emotional processes via the V1b receptor, and suggest that its blockade may represent a novel avenue for the treatment of affective disorders.