The neurobiology and control of anxious states

  title={The neurobiology and control of anxious states},
  author={Mark J Millan},
  journal={Progress in Neurobiology},
  • M. Millan
  • Published 1 June 2003
  • Biology, Psychology
  • Progress in Neurobiology
Serotonin and the neurobiology of anxious states
  • C. Lowry, M. Hale
  • Psychology, Biology
    Handbook of Behavioral Neuroscience
  • 2020
The Role of the Amygdala in Anxiety Disorders
Anxiety is a term often used to encompass feelings of apprehension, dread, unease or similarly unpleasant emotions. Trait anxiety defines the affect of an organism over time and across situations,
The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders.
The reviewed results suggest that chronic, but not acute, administration of antidepressants suppress panic attacks by increasing the release of 5-HT and enhancing the responsivity of post-synaptic 5- HT1A and5-HT2A receptors in the DPAG.
New perspectives in glutamate and anxiety
Defensive and Emotional Behavior Modulation by Serotonin in the Periaqueductal Gray.
Evidence is document evidence suggesting that the PAG-evoked behavioral responses of anxiety, panic, fear, analgesia, and aggression are influenced by the activation of 5-HT1A and 5- HT2A/C receptors and their participation in the treatment of various mental disorders.
Serotonin in anxiety and panic: Contributions of the elevated T-maze
Mesolimbic dopaminergic pathways in fear conditioning
Interactions between corticotropin-releasing hormone and serotonin: implications for the aetiology and treatment of anxiety disorders.
  • A. Linthorst
  • Psychology, Biology
    Handbook of experimental pharmacology
  • 2005
This chapter discusses studies showing that CRH and the urocortins influence several aspects of serotoninergic neurotransmission, including the firing rate of 5-HT neurones and the release and synthesis of this monoamine, and reviews data showing that long-term alterations in the CRH system lead to aberrant functioning of serotonin allergic neurotransmission under basal and/or stressful conditions.


Role of 5-HT in stress, anxiety, and depression
Corticosteroids in relation to fear, anxiety and psychopathology
  • S. Korte
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 2001
Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states
The mediators and circuitries of the stress system are reviewed to lay the groundwork for placing in context physiologic and structural alterations in depression that may occur as part of stress system dysfunction.
Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders
Findings point to a role for vasopressin in the modulation of emotional processes via the V1b receptor, and suggest that its blockade may represent a novel avenue for the treatment of affective disorders.