The neurobiological consequences of early stress and childhood maltreatment

  title={The neurobiological consequences of early stress and childhood maltreatment},
  author={Martin H. Teicher and Susan L Andersen and Ann Polcari and Carl M. Anderson and Dennis M. Kim},
  journal={Neuroscience \& Biobehavioral Reviews},

The effects of childhood maltreatment on brain structure, function and connectivity

This Review explores whether these alterations reflect toxic effects of early-life stress or potentially adaptive modifications, the relationship between psychopathology and brain changes, and the distinction between resilience, susceptibility and compensation.

Neurobiological Consequences of Early Stress and Childhood Maltreatment: Are Results from Human and Animal Studies Comparable?

Preclinical studies on the effects of exposure to early life stress can demonstrate causality, and can enrich the understanding of the clinical research if they hypothesize that the consequences of early abuse are predominantly mediated through the induction of stress responses.

The neuroendocrinological sequelae of stress during brain development: the impact of child abuse and neglect.

  • A. Panzer
  • Psychology, Biology
    African journal of psychiatry
  • 2008
Effects on the hypothalamo-pituitary-adrenal and central noradrenergic-sympathoadrenomedullary stress axes and other neurotransmitter systems are examined before turning to changes described in the cerebral volumes, corpus callosum and cortical hemispheres, prefrontal cortex and amygdalae, superior temporal gyrus, hippocampus as well as the cerebellar vermis.

Neurobiological and Behavioral Consequences of Exposure to Childhood Traumatic Stress

The developing brain is a remarkably plastic and dynamic organ. Although the basic possibilities of what it has the potential to become appears to be set by genetic codes, the unique configuration

Research review: the neurobiology and genetics of maltreatment and adversity.

A review of studies investigating the neurobiological and genetic factors associated with childhood maltreatment and adversity indicates an association between early adversity and atypical development of the hypothalamic-pituitary-adrenal axis stress response, which can predispose to psychiatric vulnerability in adulthood.

Child Maltreatment: The Neurobiological Aspects of Posttraumatic Stress Disorder

The research on trauma, its effects on the brain, and evidence-based interventions are examined and an overview of normal brain functioning and posttraumatic stress disorder is presented.

Is impulsivity a link between childhood abuse and suicide?

The Long-Term Impact of Early Life Stress on Orbitofrontal Cortical Thickness.

Investigation of the effect of LS during infancy, childhood, and adolescence on CT alterations in the OFC and on psychopathology in 190 adults of an ongoing prospective cohort study highlighted the long-term impact of early LS on an affective core brain structure and psychopathology later in life.



Developmental neurobiology of childhood stress and trauma.

Homeostasis, stress, trauma, and adaptation. A neurodevelopmental view of childhood trauma.

  • B. PerryR. Pollard
  • Psychology, Medicine
    Child and adolescent psychiatric clinics of North America
  • 1998

Effects of early adverse experiences on brain structure and function: clinical implications

The psychobiological basis of posttraumatic stress disorder.

Fear conditioning to explicit and contextual cues is proposed as a model for intrusive memories reactivated by trauma-related stimuli and hyperarousal, respectively, and it is argued that the amygdala plays a crucial role in the encoding and retrieval of fear memories activated by specific stimuli that have been associated with aversive events.

Enduring Neurochemical Effects of Early Maternal Separation on Limbic Structures

Chronic maternal deprivation subjects show activity patterns that are best characterized as restless with mild hyperactivity and reductions in serotonin (5-HT) and norepinephrine in key limbic targets, and these effects were better localized with antibodies for 5-HT and tyrosine hydroxylase.

Child abuse and neglect and the brain--a review.

  • D. Glaser
  • Psychology
    Journal of child psychology and psychiatry, and allied disciplines
  • 2000
The importance of early intervention and attention to the chronicity of environmental adversity may indicate the need for permanent alternative caregivers, in order to preserve the development of the most vulnerable children.

Early childhood abuse and limbic system ratings in adult psychiatric outpatients.

The authors investigated the hypothesis that early abuse might affect the development of the limbic system and found that physical or sexual abuse alone was associated with elevated LSCL-33 scores only if the abuse occurred before age 18.

Prenatal Stress, Glucocorticoids and the Programming of the Brain

The data suggest that key targets for programming include glucocorticoid receptor gene expression and the corticotrophin‐releasing hormone system, and that approaches to minimize or reverse the consequences of such early life events may have therapeutic importance.

Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma

In monozygotic twins discordant for trauma exposure, it is found evidence that smaller hippocampi indeed constitute a risk factor for the development of stress-related psychopathology.

A.E. Bennett Research Award. Developmental traumatology. Part II: Brain development.

It is suggested that the overwhelming stress of maltreatment experiences in childhood is associated with adverse brain development and brain volume robustly and positively correlated with age of onset of PTSD trauma and negatively correlated with duration of abuse.