The neuro-endocrine impact of 3-hydroxy-diazepam (temazepam) in women

  title={The neuro-endocrine impact of 3-hydroxy-diazepam (temazepam) in women},
  author={M. D. Beary and John Hubert Lacey and Arvind V. Bhat},
The benzodiazepines have been considered largely free of neuro-endocrine effect. However, in a double-blind, random assignment, placebo controlled study of six young women in the first half of their menstrual cycle oral temazepam (20 mg) was found to significantly lower plasma cortisol and raise plasma prolactin. The impact on cortisol was significant at 40 min and persisted for 3 h (P<0.01) after oral ingestion. Prolactin was significantly raised at 1 h after ingestion only (P<0.05). No impact… CONTINUE READING