The neurite-initiating effect of a tripeptide aldehyde protease inhibitor on PC12h cells.

@article{Saito1989TheNE,
  title={The neurite-initiating effect of a tripeptide aldehyde protease inhibitor on PC12h cells.},
  author={Yuko Saito and Seiichi Kawashima},
  journal={Journal of biochemistry},
  year={1989},
  volume={106 6},
  pages={1035-40}
}
We report here the possible involvement of a new protease in neurite initiation by PC12h cells. Addition of a leupeptin analogue (Ac-Leu-Leu-Nle-al, ALLNal) to PC12h cells on culture plates coated with collagen type I caused de novo neurite outgrowth. Other protease inhibitors (Ac-Leu-Leu-Met-al, leupeptin, E64c, E64d, soybean trypsin inhibitor, hirudin, aprotinin, diisofluorophosphate, 6-aminocapric acid, and pepstatin A) could not mimic this neurite-initiating action. ALLNal induced the… CONTINUE READING

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