The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo.

@article{SolerLlavina2011TheNL,
  title={The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo.},
  author={Gilberto J Soler-Llavina and Marc V Fuccillo and Gopal Pramanik and Thomas C S{\"u}dhof and Robert C Malenka},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 40},
  pages={16502-9}
}
Synaptic cell adhesion molecules, including the neurexin ligands, neuroligins (NLs) and leucine-rich repeat transmembrane proteins (LRRTMs), are thought to organize synapse assembly and specify synapse function. To test the synaptic role of these molecules in vivo, we performed lentivirally mediated knockdown of NL3, LRRTM1, and LRRTM2 in CA1 pyramidal cells of WT and NL1 KO mice at postnatal day (P)0 (when synapses are forming) and P21 (when synapses are largely mature). P0 knockdown of NL3 in… CONTINUE READING

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