The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.

  title={The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal synapses.},
  author={Rosana Aparecida Garcia and Kuzhalini Vasudevan and Andr{\'e}s Buonanno},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 7},
Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of their cognate tyrosine kinase receptors, ErbB 1-4. The subcellular distribution and mechanisms that regulate the localization of ErbB receptors are unknown. We have found that ErbB receptors are present in brain subcellular fractions enriched for postsynaptic densities (PSD). The ErbB-4 receptor is unique among the ErbB proteins because its C-terminal tail (T-V-V… CONTINUE READING
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