The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

@article{Pruessner2017TheND,
  title={The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities},
  author={Marita Pruessner and Alexis E. Cullen and Monica Aas and Elaine F. Walker},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2017},
  volume={73},
  pages={191-218}
}

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References

SHOWING 1-10 OF 408 REFERENCES
Stress and neurodevelopmental processes in the emergence of psychosis
Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia.
TLDR
Recent scientific findings on the role of the hypothalamic-pituitary-adrenal (HPA) axis, one of the primary neural systems triggered by stress exposure, in the expression of vulnerability for schizophrenia are examined.
Stress, the hippocampus and the hypothalamic-pituitary-adrenal axis: implications for the development of psychotic disorders.
TLDR
Evidence supporting a role for HPA-axis dysfunction in the early phase of schizophrenia and related disorders is discussed and evidence that the onset of psychotic disorders may be associated with a higher rate of stress and changes to the hippocampus is provided.
Schizophrenia: a neural diathesis-stress model.
TLDR
This neural diathesis-stress model is consistent with findings on prenatal factors and brain abnormalities in schizophrenia, and it provides a framework for explaining some key features of the developmental course and clinical presentation.
Role of cortisol in patients at risk for psychosis mental state and psychopathological correlates: A systematic review
TLDR
The present study aims to systematically review the evidence concerning the role of cortisol in patients at risk for psychosis mental state and its associations with psychopathological correlates, and finds that the evidence favors cortisol's participation in the pathophysiology of psychosis.
Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction.
TLDR
Evidence is presented suggesting that psychosocial stress may increase risk for psychosis, especially in the case of cumulative exposure, and that polymorphisms within the catechol-O-methyltransferase and brain-derived neurotrophic factor genes may interact with psychossocial stress in the development of psychosis.
The Role of Cortisol in First Episode of Psychosis: A Systematic Review
TLDR
The evidence suggests a role for cortisol in psychosis, although the association of cortisol with psychopathological symptoms is currently non-specific and future research should focus on more pure diagnostic entities, clearly defined stages of the disorder and refined methods of hormonal measurement.
Salivary cortisol in early psychosis: New findings and meta-analysis
...
1
2
3
4
5
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