The neural basis of puberty and adolescence

  title={The neural basis of puberty and adolescence},
  author={C. Sisk and D. Foster},
  journal={Nature Neuroscience},
  • C. Sisk, D. Foster
  • Published 2004
  • Medicine, Biology
  • Nature Neuroscience
  • The pubertal transition to adulthood involves both gonadal and behavioral maturation. A developmental clock, along with permissive signals that provide information on somatic growth, energy balance and season, time the awakening of gonadotropin releasing hormone (GnRH) neurons at the onset of puberty. High-frequency GnRH release results from disinhibition and activation of GnRH neurons at puberty onset, leading to gametogenesis and an increase in gonadal steroid hormone secretion. Steroid… CONTINUE READING
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