The neural basis of drug craving: An incentive-sensitization theory of addiction

@article{Robinson1993TheNB,
  title={The neural basis of drug craving: An incentive-sensitization theory of addiction},
  author={Terry E. Robinson and Kent C. Berridge},
  journal={Brain Research Reviews},
  year={1993},
  volume={18},
  pages={247-291}
}
This paper presents a biopsychological theory of drug addiction, the 'Incentive-Sensitization Theory'. The theory addresses three fundamental questions. The first is: why do addicts crave drugs? That is, what is the psychological and neurobiological basis of drug craving? The second is: why does drug craving persist even after long periods of abstinence? The third is whether 'wanting' drugs (drug craving) is attributable to 'liking' drugs (to the subjective pleasurable effects of drugs)? The… Expand
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In 1993, Robinson and Berridge published their first review that laid out the incentive sensitization theory of addiction (Robinson and Berridge 1993 Brain Res Rev 18:247). Its basic point is thatExpand
The incentive sensitization theory of addiction: some current issues
  • T. Robinson, K. Berridge
  • Psychology, Medicine
  • Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2008
TLDR
The theory that addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic systems that attribute incentive salience to reward-associated stimuli is presented. Expand
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References

SHOWING 1-10 OF 414 REFERENCES
Opponent process theory of motivation: Neurobiological evidence from studies of opiate dependence
TLDR
Neurobiological evidence is presented to support the opponent process concept and neural circuitry that may be involved that is involved in the development of an adaptive process to counter the acute effects of the drug is suggested. Expand
Classical conditioning and cognitive determinants of subjective craving for opiates: an investigation of their relative contributions.
TLDR
The present investigation has identified correlates of craving predicted by the above models, and tested them empirically, and some of the predictions of the CC formulations were borne out, and the cognitive model received more consistent support. Expand
Dopamine, addiction and reward
Abstract The role of dopamine was inferred in reward processes from early studies showing that psychomotor stimulants such as cocaine and amphetamine could facilitate intracranial self-stimulation.Expand
A psychomotor stimulant theory of addiction.
TLDR
A new attempt at a general theory of addiction is offered, based on the common denominator of the psychomotor stimulants---amphetamine, cocaine, and related drugs---rather than on thecommon denominators of the socalled depressant drugs~opiates, barbiturates, alcohol, and others. Expand
Brain mechanisms of drug reward and euphoria.
TLDR
The brain circuitry activated by two classes of abused drugs, psychomotor stimulants and opiates, is now partially understood and the current evidence suggests a shared mechanism of stimulant reward and opiate reward. Expand
A Second Look at First Effects: The Subjective Effects of Opiates on Nonaddicts
Reactions of novices to opiates range from extremely positive to completely negative, and the role these effects play in forming a drug habit has interested both scholars concerned with explainingExpand
The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence.
  • E. Khantzian
  • Psychology, Medicine
  • The American journal of psychiatry
  • 1985
Recent clinical observations and psychiatric diagnostic findings of drug-dependent individuals suggest that they are predisposed to addiction because they suffer with painful affect states andExpand
New concepts in cocaine addiction: The dopamine depletion hypothesis
TLDR
DA depletion may underlie dysphoric aspects of cocaine abstinence, and cocaine urges, and the psychological approach to these patients is discussed. Expand
Cocaine : scientific and social dimensions
Partial table of contents: Cocaine in Perspective (G. Edwards). Cocaine's History, Especially the American Experience (D. Musto). Epidemiological Research on Cocaine Use in the USA (J. Anthony).Expand
Reinforcements from the first drug experience can predict later drug habits and/or addiction: results with coffee, cigarettes, alcohol, barbiturates, minor and major tranquilizers, stimulants, marijuana, hallucinogens, heroin, opiates and cocaine.
TLDR
Of the components to the index of reinforcement, degree of liking of a drug on the first occasion was most related to the subsequent habit, and the greatest initial reinforcement scores were found for heroin, cocaine and opiates other than heroin. Expand
...
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3
4
5
...