The neural and neurocomputational bases of recovery from post-stroke aphasia

@article{Stefaniak2019TheNA,
  title={The neural and neurocomputational bases of recovery from post-stroke aphasia},
  author={James D. Stefaniak and Ajay D. Halai and Matthew. A. Lambon Ralph},
  journal={Nature Reviews Neurology},
  year={2019},
  volume={16},
  pages={43-55}
}
Language impairment, or aphasia, is a disabling symptom that affects at least one third of individuals after stroke. Some affected individuals will spontaneously recover partial language function. However, despite a growing number of investigations, our understanding of how and why this recovery occurs is very limited. This Review proposes that existing hypotheses about language recovery after stroke can be conceptualized as specific examples of two fundamental principles. The first principle… Expand
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A neurocomputational bilateral model of spoken language production is constructed to simulate a range of phenomena in healthy participants and patients with aphasia simultaneously, including language lateralisation, impaired performance after left but not right damage, and hemispheric involvement in plasticity-dependent recovery. Expand
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Instead of the language network expanding by activating novel right hemisphere regions ‘de novo’ post-stroke, as would be predicted by neurocomputational invasion/quiescent homologue engagement mechanisms of recovery, it is found that multiple regions throughout both hemispheres were consistently activated during language tasks in PSA and controls. Expand
A unified neurocomputational bilateral model of spoken language production in healthy participants and recovery in poststroke aphasia
TLDR
A neurocomputational bilateral model of spoken language production is constructed to simulate a range of phenomena in healthy participants and patients with aphasia simultaneously, including language lateralization, impaired performance after left but not right damage, and hemispheric involvement in plasticity-dependent recovery. Expand
Running Head: PERILESIONAL ACTIVITY IN APHASIA
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The results are not consistent with the conventional perilesional plasticity hypothesis, but favor an interpretation that recovery is supported by normalization of language network dysfunction and possibly recruitment of alternate brain regions. Expand
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A critical role is suggested for the posterior left middle temporal gyrus in the recovery of auditory comprehension following stroke, and that spontaneous recovery of audible comprehension can continue well beyond the first year post-stroke. Expand
Neuroplasticity in Post-Stroke Aphasia: A Systematic Review and Meta-Analysis of Functional Imaging Studies of Reorganization of Language Processing
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A systematic review and meta-analysis of all articles published between 1995 and early 2020 that have described functional imaging studies of six or more individuals with post-stroke aphasia, and have reported analyses bearing on neuroplasticity of language processing found that methodological limitations related to task performance confounds, contrast validity, and correction for multiple comparisons have been pervasive. Expand
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Lesion-symptom mapping in two large, partially-overlapping groups of aphasia patients with left hemisphere brain damage due to stroke identifies multiple measure by region interaction effects, associating damage to the posterior middle temporal gyrus with syntactic comprehension deficits, damage to posterior inferior frontal gyrusWith expressive agrammatism, and damage to inferior angular gyruswith semantic category word fluency deficits. Expand
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