The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.

@article{Imai2001TheNR,
  title={The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.},
  author={Takao Imai and Ayumi Tokunaga and Teruhiko Yoshida and Muneaki Hashimoto and Katuhiko Mikoshiba and Geraldine Weinmaster and Masato Nakafuku and Hideyuki Okano},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 12},
  pages={
          3888-900
        }
}
Musashi1 (Msi1) is an RNA-binding protein that is highly expressed in neural progenitor cells, including neural stem cells. In this study, the RNA-binding sequences for Msi1 were determined by in vitro selection using a pool of degenerate 50-mer sequences. All of the selected RNA species contained repeats of (G/A)U(n)AGU (n = 1 to 3) sequences which were essential for Msi1 binding. These consensus elements were identified in some neural mRNAs. One of these, mammalian numb (m-numb), which… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 197 CITATIONS, ESTIMATED 44% COVERAGE

Natural product (-)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1.

  • Molecular oncology
  • 2015
VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

A conserved three-nucleotide core motif defines Musashi RNA binding specificity.

  • The Journal of biological chemistry
  • 2014
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2001
2019

CITATION STATISTICS

  • 33 Highly Influenced Citations

  • Averaged 11 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 75 REFERENCES

Mouse numb is an essential gene involved in cortical neurogenesis.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2000

Musashi1: evolutionarily conserved markers for CNS progenitor cells including neural stem cells

Y. Kaneko, S. Sakakibara, +6 authors H. Okano
  • Dev . Neurosci .
  • 2000