The nephrotic syndrome at presentation of insulin-dependent diabetes mellitus; cause or coincidence?

@article{Dornan1988TheNS,
  title={The nephrotic syndrome at presentation of insulin-dependent diabetes mellitus; cause or coincidence?},
  author={Tim Dornan and Sarah Jenkins and Ros Cotton and R. B. Tattersall and Richard P Burden},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={1988},
  volume={5 4},
  pages={387-90}
}
Two young women developed the nephrotic syndrome within 2 weeks of presenting with diabetes and starting insulin. One had a renal biopsy which showed changes consistent with 'minimal change nephrotic syndrome' on electron microscopy but no evidence of diabetic glomerulosclerosis. Neither patient received steroids; in one the oedema resolved spontaneously but the other required diuretics. This patient also had severe IgA-deficiency probably associated with epilepsy and/or phenytoin therapy and… CONTINUE READING