The nephropathy of cystic fibrosis: a human model of chronic nephrotoxicity.

@article{Abramowsky1982TheNO,
  title={The nephropathy of cystic fibrosis: a human model of chronic nephrotoxicity.},
  author={Carlos R. Abramowsky and G L Swinehart},
  journal={Human pathology},
  year={1982},
  volume={13 10},
  pages={934-9}
}
Patients with cystic fibrosis are chronically exposed to several potentially nephrotoxic factors. These include bacterial infections with their associated immune complexes and the antibiotics (aminoglycosides) used in their treatment. In addition, diabetes mellitus, liver disease, and cor pulmonale, commonly seen in these patients, may produce renal injury. To assess the extent of this injury, we performed morphologic and immunopathologic studies of the kidneys of 34 patients at autopsy. The… CONTINUE READING

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