The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles

@article{Breese2005TheNR,
  title={The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles},
  author={George R. Breese and Darin J. Knapp and Hugh E. Criswell and Sheryl S. Moy and Bonita L. Blake},
  journal={Brain Research Reviews},
  year={2005},
  volume={48},
  pages={57-73}
}
In 1973, a technique of administering 6-hydroxydopamine (2,4,5-trihydroxyphenylethylamine) intracisternally to neonate rats was introduced to selectively reduce brain dopamine (neonate-lesioned rat). This neonate treatment proved unique when compared to rats lesioned as adults with 6-hydroxydopamine--prompting the discovery of differing functional characteristics resulting from the age at which brain dopamine is reduced. A realization was that neonate-lesioned rats modeled the loss of central… CONTINUE READING

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