The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy.

@article{Sockolosky2015TheNF,
  title={The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy.},
  author={Jonathan T Sockolosky and Francis C. Szoka},
  journal={Advanced drug delivery reviews},
  year={2015},
  volume={91},
  pages={109-24}
}
Immunoglobulin G (IgG)-based drugs are arguably the most successful class of protein therapeutics due in part to their remarkably long blood circulation. This arises from IgG interaction with the neonatal Fc receptor, FcRn. FcRn is the central regulator of IgG and albumin homeostasis throughout life and is increasingly being recognized as an important player in autoimmune disease, mucosal immunity, and tumor immune surveillance. Various engineering approaches that hijack or disrupt the FcRn… CONTINUE READING

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