The negative inotropic effect of beta3-adrenoceptor stimulation in the beating guinea pig heart.

@article{Kitamura2000TheNI,
  title={The negative inotropic effect of beta3-adrenoceptor stimulation in the beating guinea pig heart.},
  author={Takatoshi Kitamura and Katsuya Onishi and Kaoru Dohi and Tsutomu Okinaka and Naoki Isaka and Takeshi Nakano},
  journal={Journal of cardiovascular pharmacology},
  year={2000},
  volume={35 5},
  pages={786-90}
}
Although beta3-adrenoceptors (ARs) have been extensively characterized in brown and white adipocytes, their actions in the beating heart are unclear. We examined the effects of a beta3-AR agonist, BRL37344, on cardiac function and calcium transients in Langendorff-perfused guinea pig hearts by simultaneously measuring left ventricular (LV) pressure and Ca2+-dependent indo-1 fluorescence. BRL37344 induced a dose-dependent negative inotropic effect at concentrations from 10(-11) to 10(-8) M… CONTINUE READING

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