The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.

@article{Gauthier1998TheNI,
  title={The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.},
  author={Catherine Gauthier and V{\'e}ronique Leblais and Lester Kobzik and Jean-no{\"e}l Trochu and Nassirah Khandoudi and Alfred Bril and Jean-Luc Balligand and Herv{\'e} Le Marec},
  journal={The Journal of clinical investigation},
  year={1998},
  volume={102 7},
  pages={1377-84}
}
Beta1- and beta2-adrenoceptors in heart muscle cells mediate the catecholamine-induced increase in the force and frequency of cardiac contraction. Recently, in addition, we demonstrated the functional expression of beta3-adrenoceptors in the human heart. Their stimulation, in marked contrast with that of beta1- and beta2-adrenoceptors, induces a decrease in contractility through presently unknown mechanisms. In the present study, we examined the role of a nitric oxide (NO) synthase pathway in… CONTINUE READING
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