The negative feedback effects of testicular steroids are predominantly at the hypothalamus in the ram.

@article{Tilbrook1991TheNF,
  title={The negative feedback effects of testicular steroids are predominantly at the hypothalamus in the ram.},
  author={Alan J. Tilbrook and David Morritz de Kretser and J T Cummins and I. J. Clarke},
  journal={Endocrinology},
  year={1991},
  volume={129 6},
  pages={3080-92}
}
This study aimed to delineate the hypothalamic and/or pituitary actions of testosterone and its primary metabolites 5 alpha-dihydrotestosterone and estradiol (E) in adult castrated rams (wethers) during the breeding season. In Exp 1, wethers were treated for a week with twice daily injections (im) of peanut oil, 8, 16 or 32 mg/day testosterone propionate (TP) or dihydrotestosterone benzoate (DHTB) or an sc silastic implant containing 1 or 3 cm E. TP decreased plasma LH concentrations, increased… CONTINUE READING

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