The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus.

@article{Kenjale2005TheNC,
  title={The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus.},
  author={Roma Kenjale and Justin W Wilson and Sebastian F Zenk and Saroj Saurya and Wendy L. Picking and William D. Picking and Ariel Blocker},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 52},
  pages={42929-37}
}
Gram-negative bacteria commonly interact with eukaryotic host cells by using type III secretion systems (TTSSs or secretons). TTSSs serve to transfer bacterial proteins into host cells. Two translocators, IpaB and IpaC, are first inserted with the aid of IpaD by Shigella into the host cell membrane. Then at least two supplementary effectors of cell invasion, IpaA and IpgD, are transferred into the host cytoplasm. How TTSSs are induced to secrete is unknown, but their activation appears to… CONTINUE READING