The need to move from 6-minute walk distance to outcome trials in pulmonary arterial hypertension.

@article{Gaine2013TheNT,
  title={The need to move from 6-minute walk distance to outcome trials in pulmonary arterial hypertension.},
  author={Sean Patrick Gaine and G{\'e}rald Simonneau},
  journal={European respiratory review : an official journal of the European Respiratory Society},
  year={2013},
  volume={22 130},
  pages={
          487-94
        }
}
Assessment of change in exercise capacity using the 6-min walk distance (6MWD) test has been the primary end-point in the majority of pulmonary arterial hypertension (PAH) clinical trials. The 6MWD has some advantages as an end-point in such studies. It is simple and inexpensive to perform, reproducible and validated. In short-term studies with small patient numbers, as is typical in a rare disease like PAH, using change from baseline in 6MWD as the primary outcome measure demonstrated… CONTINUE READING
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