The need for reappraisal of type 2 diabetes mellitus management.

@article{Wyne2003TheNF,
  title={The need for reappraisal of type 2 diabetes mellitus management.},
  author={Kathleen Louise Wyne},
  journal={Postgraduate medicine},
  year={2003},
  volume={Spec No},
  pages={
          5-14
        }
}
Type 2 diabetes is a multiorgan disease that results from the combination of insulin resistance and a beta-cell secretory defect. Because the complications associated with this disease are so significant, the importance of lowering glycosylated hemoglobin levels to within the normal range cannot be overemphasized. Thiazolidinediones (TZDs) modulate lipid metabolism, improve insulin sensitivity, exert numerous nonglycemic effects on the vasculature and lipid metabolism, and may improve many risk… CONTINUE READING