The necessity to revise Koch’s postulates and its application to infectious and non-infectious diseases: a mini-review

  title={The necessity to revise Koch’s postulates and its application to infectious and non-infectious diseases: a mini-review},
  author={Hasan Hosainzadegan and Rovshan Khalilov and Pourya Gholizadeh},
  journal={European Journal of Clinical Microbiology \& Infectious Diseases},
Advances in the science have promoted all aspects of human’s life; these, in turn, have changed many principles and scientific postulates. Koch’s postulates, since the beginning of their implementation, have been one of the important subjects involving complications and misinterpretations regarding the causal relationship of microbe-hosts. These postulates have been shown not to be correct in some cases including the inability of some microbes to grow in the culture medium, viruses, or… Expand
5 Citations
A gut dysbiotic microbiota-based hypothesis of human-to-human transmission of non-communicable diseases.
Reports on environmental factors, including a high-fat diet, alcohol, smoking, exercise, radiation and air pollution, which have been associated with dysbiotic microbiota, and whether any of these parameters were also associated with NCDs are reviewed. Expand
Identification of a new orthonairovirus associated with human febrile illness in China.
A new orthonairovirus, Songling virus (SGLV), is identified from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China and is associated with human febrile illness in China. Expand
Identification of a new orthonairovirus associated with human febrile illness in China
A novel orthonairovirus is identified, designated Sōnglǐng virus (SGLV), from patients who reported being bitten by a tick in China, and it was shown to be associated with human febrile illness in northeastern China. Expand
Oil Palm Fatal Yellowing (FY), a Disease with an Elusive Causal Agent
An overview of the history of this disease and the several efforts done to fulfill Koch’s postulates over the last 40 years are presented, besides discussing recent studies that revisited this subject using some omics technics. Expand
Applying Concepts of Causal Inference to Infectious Bovine Keratoconjunctivitis.
  • A. O'Connor
  • Medicine
  • The Veterinary clinics of North America. Food animal practice
  • 2021
Bradford Hill viewpoints are used to discuss the evidence base for Moraxella bovis and Moraxlla bovoculi being component causes of infectious bovine keratoconjunctivitis. Expand


From Koch's Postulates to Biofilm Theory. The Lesson of Bill Costerton
This Editorial and the entire 2012 issue “Focus on Implant Infections” are dedicated to the memory of Bill Costerton, recognized worldwide as the Father of Biofilms for his innovation and body of work on infections caused by sessile bacteria. Expand
Cell Wall-Deficient Bacteria as a Cause of Infections: A Review of the Clinical Significance
The evidence for the clinical significance of CWDB in disease is not compelling and a number of case reports and laboratory studies suggest some disease associations, however. Expand
The Role of Biofilms: Are We Hitting the Right Target?
Biofilm phenotype bacteria predominate on the surface of wounds, and biofilm-based management improves wound healing outcomes, indicating that biofilm is the right target for managing the bioburden barrier of chronic wounds. Expand
The dormant blood microbiome in chronic, inflammatory diseases
Overall, it seems that many more chronic, non-communicable, inflammatory diseases may have a microbial component than are presently considered, and may be treatable using bactericidal antibiotics or vaccines. Expand
New insights into bacterial persistence in reactive arthritis.
Both modes of persistence, cell wall-deficient state of bacteria and bacterial biofilms, deserve rheumatologists' attention, as their investigation, applying modern standardized methods, may contribute to the elaboration of new beneficial schemes of antibacterial ReA therapy. Expand
L-form bacteria, chronic diseases and the origins of life
L-forms provide an interesting model system for studying early steps in the evolution of cellular life, and are potentially important in biotechnology, because lack of a wall can be advantageous in a range of production or strain improvement applications. Expand
Towards diagnostic guidelines for biofilm-associated infections.
This review is designed to give an overview of biofilm-associated infections (BAI) and to propose a platform for further discussion that includes clinicians, medical microbiologists, and biofilm researchers who are stakeholders in advancing the scientific pursuit of better diagnosis and treatment of BAI to mitigate their human and healthcare costs. Expand
Microbial balance in the intestinal microbiota and its association with diabetes, obesity and allergic disease.
Well-characterized underlying mechanisms may provide novel strategies for using prebiotic and probiotic to prevent and treatment of allergic diseases, obesity, diabetes, and other lifestyle-related disorders. Expand
Abnormal morphology of bacteria in the sputa of patients treated with antibiotics
It was suspected that the low dose of cefazolin and the intermittent therapy with ampicillin resulted in a subminimum inhibitory concentration of antibiotic in the respiratory tract which induced the the abnormal morphology of the bacteria observed in the sputum of both patients. Expand
Bacterial L‐forms require peptidoglycan synthesis for cell division
  • J. Casadesús
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2007
The classical definition of L‐forms as cell‐wall‐less bacterial variants may need a revision to accomodate recent observations, as genetic and biochemical evidence indicates that E. coli L‐ forms induced by β‐lactam antibiotics do contain small amounts of peptidoglycan, essential for their growth and probably required for septum formation. Expand