The nature of the stimulation of the respiratory chain of rat liver mitochondria by glucagon pretreatment of animals.

  title={The nature of the stimulation of the respiratory chain of rat liver mitochondria by glucagon pretreatment of animals.},
  author={Andrew P. Halestrap},
  journal={The Biochemical journal},
  volume={204 1},
  • A. Halestrap
  • Published 15 April 1982
  • Biology, Computer Science
  • The Biochemical journal
1. Studies on the cytochrome spectra of liver mitochondria from control and glucagon-treated rats in State 4, State 3 and in the presence of uncoupler are reported. 2. The stimulation of electron flow between cytochromes c1 and c observed previously [Halestrap (1978) Biochem. J. 172, 399-405] was shown to be an artefact of Ca2+-induced swelling of mitochondria. 3. When precautions were taken to prevent such swelling, glucagon treatment was shown to enhance the reduction of cytochromes c, c1 and… 

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