The nature of nurture: effects of parental genotypes

@inproceedings{Kong2017TheNO,
  title={The nature of nurture: effects of parental genotypes},
  author={Augustine Kong and Gudmar Thorleifsson and Michael L Frigge and Bjarni J. Vilhj{\'a}lmsson and Alexander I Young and Thorgeir E. Thorgeirsson and Stefania Benonisdottir and Asmundur Oddsson and Bjarni V. Halldorsson and Gisli M{\`a}sson and Daniel Fannar Gudbjartsson and Agnar Helgason and Gyda Bjornsdottir and Unnur Thorsteinsd{\'o}ttir and K{\'a}ri Stef{\'a}nsson},
  year={2017}
}
Sequence variants in the parental genomes that are not transmitted to a child/proband are often ignored in genetic studies. Here we show that non-transmitted alleles can impact a child through their effects on the parents and other relatives, a phenomenon we call genetic nurture. Using results from a meta-analysis of educational attainment, the polygenic score computed for the non-transmitted alleles of 21,637 probands with at least one parent genotyped has an estimated effect on the… CONTINUE READING

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