The nature of dopamine dysfunction in schizophrenia and what this means for treatment.

@article{Howes2012TheNO,
  title={The nature of dopamine dysfunction in schizophrenia and what this means for treatment.},
  author={Oliver D. Howes and Joseph Kambeitz and Euitae Kim and Daniel St{\aa}hl and Mark Slifstein and Anissa Abi-Dargham and Shitij Kapur},
  journal={Archives of general psychiatry},
  year={2012},
  volume={69 8},
  pages={
          776-86
        }
}
CONTEXT Current drug treatments for schizophrenia are inadequate for many patients, and despite 5 decades of drug discovery, all of the treatments rely on the same mechanism: dopamine D(2) receptor blockade. Understanding the pathophysiology of the disorder is thus likely to be critical to the rational development of new treatments for schizophrenia. OBJECTIVE To investigate the nature of the dopaminergic dysfunction in schizophrenia using meta-analysis of in vivo studies. DATA SOURCES The… CONTINUE READING
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