The nature and identification of quantitative trait loci: a community's view

  title={The nature and identification of quantitative trait loci: a community's view},
  author={Members of the Complex Trait Consortium},
  journal={Nature Reviews Genetics},
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL? 

Limitation of Number of Strains and Persistence of False Positive Loci in QTL Mapping Using Recombinant Inbred Strains

The results indicated that studies using RI strains of less than 30 in general have a higher probability of failing to detect reliable QTL, and thousands of reported QTL from studies of RI strains may need to be double-checked for accuracy before proceeding to causal gene identification.

Gene Expression Profiling as a Tool for Positional Cloning of Genes-Shortcut or the Longest Way Round

This review uses the identification of quantitative trait loci in arthritis animal models as an illustrative example that “very likely candidate genes” identified by genomic/proteomics is not necessarily the same as true QTL underlying genes.

Germplasm Resources for MappingQuantitative Traits in Maize

The expression of quantitative traits is complex, often the result of multiple genes acting in concert, and interacting with the environment. Determining the genetic control of quantitative traits

Strategy for mapping quantitative trait loci (QTL) by using human metapopulations.

Early epidemiological assessment supports the feasibility of the proposed QT mapping strategy and clusters of individuals with extreme QT values responsible for over-representation of single villages can usually be linked to a larger pedigree and may be useful for further QTL mapping, using linkage analysis.

Systems Genetics

This protocol is intended to help investigators make more informed decisions about choices of resources given different types of questions, and recommends using complementary resources and minimizing depth of resampling of any given genome or strain.

Quantitative Trait Loci (QTL) Associated with Resistance to a Monogenean Parasite (Benedenia seriolae) in Yellowtail (Seriola quinqueradiata) through Genome Wide Analysis

This is the first genetic evidence that contributes to detailing phenotypic resistance to Benedenia disease, and the results will help resolve the mechanism of resistance to this important parasitic infection of yellowtail.

Quest for arthritis-causative genetic factors in the rat.

  • B. Joe
  • Biology
    Physiological genomics
  • 2006
Proof of principle for substitution mapping as a successful method for QTL gene discovery is provided by the positional cloning of Ncf1 as one of the arthritis QTLs in rats, which is encouraging for similar sustained dissection of all the other arthritisQTLs mapped in the rat.

Linkage mapping and quantitative trait loci analysis of sweetness and other fruit quality traits in papaya

This study has extended knowledge on the inheritance and genetic control for key papaya physiological and fruit quality traits and represents a valuable resource for the future of strategic selective breeding of elite Australian papaya cultivars.

Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice[S]

This study shows how bioinformatics can be used effectively to reduce candidate gene lists for QTL related to complex traits using a “toolbox” of bioinformatic resources.

Physical linkage and mate preference generate linkage disequilibrium for behavioral isolation in two parapatric crickets

It is suggested that the finely-tuned, highly divergent preference functions are likely an additional source of LD between male and female traits in this system and pleiotropy of gene expression presents an underappreciated mechanism to link sexually dimorphic phenotypes.