The nature and identification of quantitative trait loci: a community's view

@article{Abiola2003TheNA,
  title={The nature and identification of quantitative trait loci: a community's view},
  author={Oduola Abiola and Joe M. Angel and Philip Avner and Alexander A. Bachmanov and John K. Belknap and Beth Bennett and Elizabeth P. Blankenhorn and David A. Blizard and Valerie J. Bolivar and Gundrun A Brockmann and Kari Johnson Buck and Jean-Francoise Bureau and William L. Casley and Elissa J. Chesler and James M. Cheverud and Gary A. Churchill and Melloni N. Cook and John C. Crabbe and Wim E Crusio and Ariel Darvasi and Gerald de Haan and Peter Dermant and Rebecca W. Doerge and Rosemary Elliot and Charles R. Farber and Lorraine Flaherty and Jonathan Flint and Howard K. Gershenfeld and John P Gibson and Jing Gu and Weikuan Gu and Heinz Himmelbauer and Robert Hitzemann and Hui-Chen Hsu and Kent W. Hunter and Fuad Iraqi and Ritsert C. Jansen and Thomas E. Johnson and Byron C. Jones and Gerd Kempermann and Frank Lammert and Lu Lu and Kenneth F. Manly and Douglas B Matthews and Juan F. Medrano and Margarete Mehrabian and Guy Mittlemann and Beverly A. Mock and Jeffrey S. Mogil and Xavier Montagutelli and Grant Morahan and John D. Mountz and Hiroki Nagase and Richard S. Nowakowski and Bruce F. O’Hara and Alexander Osadchuk and Beverly J. Paigen and Abraham A. Palmer and Jeremy Peirce and Daniel Pomp and Michael Rosemann and Glenn D. Rosen and Leonard C. Schalkwyk and Ze’ev Seltzer and Stephen H. Settle and Kazuhiro Shimomura and Siming Shou and James M. Sikela and Linda D Siracusa and Jimmy L. Spearow and Cory Teuscher and David W. Threadgill and Linda A. Toth and Ayo A. Toye and Csaba Vad{\'a}sz and Gary van Zant and Edward K. Wakeland and Robert W. Williams and Huang-Ge Zhang and Fei Zou},
  journal={Nature Reviews Genetics},
  year={2003},
  volume={4},
  pages={911-916}
}
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL? 

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Average semivariance yields accurate estimates of the fraction of marker-associated genetic variance and heritability in complex trait analyses

The accuracy of statistical methods for estimating the fraction of marker-associated genetic variance (p) and heritability for large-effect loci underlying complex phenotypes, and it is found that commonly used statistical methods overestimate p and .
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