The naturally occurring variant of estrogen receptor (ER) ERDeltaE7 suppresses estrogen-dependent transcriptional activation by both wild-type ERalpha and ERbeta.

@article{Pedrero2003TheNO,
  title={The naturally occurring variant of estrogen receptor (ER) ERDeltaE7 suppresses estrogen-dependent transcriptional activation by both wild-type ERalpha and ERbeta.},
  author={Juana Maria Garcia Pedrero and Pedro Zuazua and Carlos M Mart{\'i}nez-Campa and Pedro S. Lazo and Sof{\'i}a Ramos},
  journal={Endocrinology},
  year={2003},
  volume={144 7},
  pages={2967-76}
}
We have isolated and functionally characterized the exon 7-skipped variant (ERDeltaE7) of estrogen receptor (ER)alpha, which has emerged as the predominant variant expressed in multiple normal and tumoral tissues. However, to date no function has been established for this variant in mammalian cells. ERDeltaE7 exhibits a negligible ability to bind ligands, insensitivity to allosteric modulation by estrogen and antiestrogens, and loss of estrogen-dependent interaction with p160 coactivators such… CONTINUE READING