The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma.

@article{Gunn2011TheNP,
  title={The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma.},
  author={Ellen J Gunn and John T. Williams and Daniel T Huynh and Michael J Iannotti and Changho Han and Francis J Barrios and Stephen Kendall and Carlotta A. Glackin and David A Colby and Julia Kirshner},
  journal={Leukemia & lymphoma},
  year={2011},
  volume={52 6},
  pages={1085-97}
}
Multiple myeloma (MM) is an incurable plasma cell malignancy where nearly all patients succumb to a relapse. The current preclinical models of MM target the plasma cells, constituting the bulk of the tumor, leaving the cancer stem cells to trigger a relapse. Utilizing a three-dimensional tissue culture system where cells were grown in extracellular matrix… CONTINUE READING