The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells

  title={The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells},
  author={B. Plitzko and E. N. Kaweesa and S. Loesgen},
  journal={The Journal of Biological Chemistry},
  pages={21102 - 21116}
  • B. Plitzko, E. N. Kaweesa, S. Loesgen
  • Published 2017
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Mensacarcin is a highly oxygenated polyketide that was first isolated from soil-dwelling Streptomyces bacteria. It exhibits potent cytostatic properties (mean of 50% growth inhibition = 0.2 μm) in almost all cell lines of the National Cancer Institute (NCI)-60 cell line screen and relatively selective cytotoxicity against melanoma cells. Moreover, its low COMPARE correlations with known standard antitumor agents indicate a unique mechanism of action. Effective therapies for managing melanoma… CONTINUE READING
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