The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1

@article{Kim2015TheNP,
  title={The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1},
  author={Juewon Kim and Young-Gyu Kang and Jee-Young Lee and Dong-Hwa Choi and Young-Uk Cho and Jae Min Shin and Jun Seong Park and John Hwan Lee and Wan Gi Kim and Dae Bang Seo and Tae Ryong Lee and Yusei Miyamoto and Kyoung Tai No},
  journal={Molecular and Cellular Endocrinology},
  year={2015},
  volume={412},
  pages={216-225}
}
Dehydroabietic acid (DAA) is a naturally occurring diterpene resin acid of confers, such as pinus species (P. densiflora, P. sylvestris) and grand fir (Abies grandis), and it induces various biological actions including antimicrobial, antiulcer, and cardiovascular activities. The cellular targets that mediate these actions are largely unknown yet. In this report, we suggest that DAA is an anti-aging reagent. DAA has lifespan extension effects in Caenorhabditis elegans, prevents lipofuscin… 
Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways
  • Eunji Kim, Young-Gyu Kang, +7 authors Jae Youl Cho
  • Medicine, Chemistry
    International journal of molecular sciences
  • 2019
TLDR
The findings demonstrate the anti-inflammatory effects and molecular mechanism of DAA and suggest that DAA has potential as a drug or supplement to ameliorate inflammation.
Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans
TLDR
This review summarized the aging and longevity pathways that are common to C. elegans and humans and collated some of the bioactive phytochemicals with health benefits and lifespan extending effects that have been studied in the Caenorhabditis elegans aging model.
The natural phytochemical trans‐communic acid inhibits cellular senescence and pigmentation through FoxO3a activation
TLDR
Results strongly suggest that TCA prevents the senescent phenotype of model organisms and exhibits beneficial effects on ageing‐related skin phenotypes through direct FoxO3a activation.
Analyzing the Synergistic Effects of Antioxidants in Combating Photoaging Using Model Nematode, Caenorhabditis elegans
TLDR
Pronounced synergistic effects were observed during UV‐A‐mediated stress conditions, suggesting that these could be used as potential antiphotoaging compounds which will be of greater significance for health‐based research.
New phytochemicals as potential human anti-aging compounds: Reality, promise, and challenges
TLDR
A critical review on aspects related to the use of novel phytochemicals asAnti-aging agents is provided, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives.
Dehydroabietic acid isolated from Pinus elliottii exerts in vitro antileishmanial action by pro-oxidant effect, inducing ROS production in promastigote and downregulating Nrf2/ferritin expression in amastigote forms of Leishmania amazonensis.
TLDR
DHA was effective in the elimination of L. amazonensis both in its promastigote forms by apoptosis-like mechanisms and intracellular form by ROS production, and also caused downregulation of Nrf2 and ferritin expression.
Dehydroabietic Acid Induces Regeneration of Collagen Fibers in Ultraviolet B-Irradiated Human Dermal Fibroblasts and Skin Equivalents
TLDR
The results suggest that DAA could be a useful agent for improving skin photoaging through the protection and regeneration of collagen fibers in skin.
Synthesis and In Vitro Anticancer Activity of Novel Dehydroabietic Acid-Based Acylhydrazones
TLDR
Screening results revealed that many of the compounds showed moderate to high levels of anticancer activities against the tested cancer cell lines and some displayed similar potent inhibitory activities to the commercial anticancer drug cisplatin, while they exhibited lower cytotoxicity against normal human liver cell (HL-7702).
Nectandrin B-mediated activation of the AMPK pathway prevents cellular senescence in human diploid fibroblasts by reducing intracellular ROS levels
TLDR
Results suggest that NecB-induced protection against cellular senescence is mediated by ROS-scavenging through activation of AMPK, and might be useful in ameliorating age-related diseases and extending human lifespan.
Synthesis and Evaluation of New Quinoxaline Derivatives of Dehydroabietic Acid as Potential Antitumor Agents
TLDR
A series of new quinoxaline derivatives of dehydroabietic acid (DAA) were designed and synthesized as potential antitumor agents and confirmed that compound 4b could induce the apoptosis of SMMC-7721 cells in a dose-dependent manner.
...
1
2
3
4
...

References

SHOWING 1-10 OF 55 REFERENCES
Dehydroabietic acid, a diterpene, improves diabetes and hyperlipidemia in obese diabetic KK‐Ay mice
TLDR
Treatment with DAA improves the levels of plasma glucose, plasma insulin, plasma TG, and hepatic TG through the decrease in the macrophage infiltration into adipose tissues, suggesting that DAA is a useful food‐derived compound for treating obesity‐related diseases.
SIRT1 Activation by Small Molecules
TLDR
It is found that some STACs can accelerate the SIRT1-catalyzed deacetylation of specific unlabeled peptides composed only of natural amino acids, in contrast to studies reporting that peptides must bear a fluorophore for their de acetylation to be accelerated.
Substrate-specific Activation of Sirtuins by Resveratrol*
TLDR
It is shown here that resveratrol is a substrate-specific activator of yeast Sir2 and human SirT1 and that in three different yeast strain backgrounds, resver atrol has no detectable effect on Sir2 activity in vivo, as measured by rDNA recombination, transcriptional silencing near telomeres, and life span.
Small-molecule allosteric activators of sirtuins.
TLDR
Although considerable progress has been made regarding Sirt1 allosteric activation, key questions remain, including how the molecular contacts facilitate SIRT1 activation, whether other sirtuin family members will be amenable to activation, and whether STACs will ultimately prove safe and efficacious in humans.
A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol
TLDR
It is shown that resveratrol inhibits human Sirt3 and stimulates Sirt5, in addition to Sirt1, against fluorophore-labeled peptide substrates but also against peptides and proteins lacking the non-physiological fluorophores modification.
Biological effects of resveratrol.
TLDR
This review focuses on various biological aspects of resveratrol and some issues that need to be addressed to gain a fuller appreciation of potential health benefits for human beings.
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity.
TLDR
How hormetic dose responses are mediated for endogenous cellular defense pathways including sirtuin, Nrfs and related pathways that integrate adaptive stress responses in the prevention of neurodegenerative diseases is described in mechanistic detail.
SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1♦
TLDR
It is concluded that SRT1720, its structurally related compounds SRT2183 and SRT1460, and resveratrol are not direct activators of SIRT1, which exhibits multiple off-target activities against receptors, enzymes, transporters, and ion channels.
Crystal structures of Sirt3 complexes with 4'-bromo-resveratrol reveal binding sites and inhibition mechanism.
TLDR
Crystal structures of Sirt3 in complex with a fluorophore-labeled and with a native substrate peptide, respectively, in presence of 4'-bromo-resveratrol reveal two compound binding sites that might indicate the site for Sirt1 activation.
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
TLDR
SIRT1 can be directly activated through an allosteric mechanism common to chemically diverse STACs, and specific hydrophobic motifs found in SIRT1 substrates such as PGC-1α and FOXO3a facilitate Sirtuin-activating compounds (STACs) activation by STacs.
...
1
2
3
4
5
...