The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse

@article{Marut2013TheNO,
  title={The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse},
  author={W. Marut and Vincent Jamier and N. Kavian and A. Servettaz and P. Winyard and P. Eggleton and A. Anwar and C. Nicco and C. Jacob and C. Ch{\'e}reau and B. Weill and F. Batteux},
  journal={Arthritis Research \& Therapy},
  year={2013},
  volume={15},
  pages={R167 - R167}
}
IntroductionThe aim of this study was to test the naturally occurring organosulfur compound dipropyltetrasulfide (DPTTS), found in plants, which has antibiotic and anticancer properties, as a treatment for HOCl-induced systemic sclerosis in the mouse.MethodsThe prooxidative, antiproliferative, and cytotoxic effects of DPTTS were evaluated ex vivo on fibroblasts from normal and HOCl mice. In vivo, the antifibrotic and immunomodulating properties of DPTTS were evaluated in the skin and lungs of… Expand
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